來源丨Science、安徽醫(yī)科大學等

1月6日，國際頂級期刊《科學》NextGen VOICES專欄刊登了安徽醫(yī)科大學第一臨床醫(yī)學院2018級臨床醫(yī)學（“5+3”一體化）專業(yè)本科生張寧同學的通訊短評《失敗的收獲》（The fruits of failure）。

這也是安徽醫(yī)科大學本科生首次在《科學》NextGen VOICES專欄上發(fā)表通訊短評。

同期登上science的還有來自中國科技大學的Yongsheng Ji、貴州大學的Yuan Zhi等2位同學共計3位來自國內高校同學。

據悉，《科學》雜志每月刊登一期NextGen VOICES專欄，面向全世界的青年科學家征集科學技術及相關領域新鮮問題的評論文章。本次NextGen VOICES專欄聚焦“挫折教育”，邀請青年科研工作者分享“科學生涯中經歷過挫折但心存感激”的故事。

在短評中，張寧以“跨學科合作”為主題，結合自身在線粒體遺傳學領域的科研經歷，講述了在建立致病線粒體DNA突變的遺傳風險預測模型中遇到的困難，并最終通過跨學科合作順利解決的故事。他認為，跨學科合作在開展學術研究和推動醫(yī)學發(fā)展中發(fā)揮了重要作用，促進醫(yī)學與生物工程、計算機技術和人工智能等多學科融合意義重大。該短評得到了《科學》NextGen VOICES專欄編委的認可，這也是安徽醫(yī)科大學本科生首次在《科學》NextGen VOICES專欄上發(fā)表通訊短評。

張寧在校期間積極投身創(chuàng)新創(chuàng)業(yè)與志愿服務活動，曾獲評安徽省“十佳大學生”、安徽“青年志愿者優(yōu)秀個人”稱號、中國大學生知行促進計劃“榜樣100”全國優(yōu)秀大學生個人、安徽醫(yī)科大學“十佳本科生”、“悅群十佳創(chuàng)新創(chuàng)業(yè)之星”等多項榮譽，目前，張寧已經以第一作者（或共同第一作者）在JCR 1區(qū)發(fā)表了4篇SCI，參與發(fā)表論文3篇，申報國家發(fā)明專利3項、實用新型專利1項并獲得授權。

文章全文如下：

The fruits of failure

We asked young scientists:?Are you grateful for a setback that you experienced? What mistake did you make, and what good came from it??In the responses below, they share the discoveries and revelations that made their would-be regrets worthwhile. Follow NextGen Voices on Twitter with hashtag #NextGenSci. —Jennifer Sills

Interdisciplinary collaboration

After many unsuccessful attempts to produce diffraction-quality protein crystals, I finally asked others for help. By doing so, I changed my routine from solo lab work to collaboration, which gave me a broader understanding of the challenges faced by experts, peers, and junior scientists. Viewing mentorship and science funding from the lens of a struggling scientist led me to a new career. I became a grants manager at a funding body, where I was responsible for science communication, grant writing workshops, collaboration, and networking events for scientists. As a science administrator, I could enhance the quality of science through funding, building capacity for addressing the “behind the scenes” matters of research. If I had not faced failure working in silos in a lab, I would never have discovered my passion.

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Two years ago, I was trying to construct mathematical models for predicting the risk of maternal inheritance of pathogenic mtDNA mutations. As a medical student, I seldom receive mathematics training. After struggling for a month, I turned to a friend studying information science for help. He solved the functions easily, making me realize the importance of interdisciplinary collaboration. Last year, we established an organization dedicated to promoting the integration of medicine and other disciplines, including bioengineering, computer technology, and artificial intelligence.

Ning Zhang First School of Clinical Medicine, Anhui Medical University, Hefei, Anhui 230032, China. Email: ningzhangbox@163.com

Writing opportunities

I’m currently taking 2 extra years of college because I wanted to keep up an adequate academic performance in classes and extracurricular research projects as well as prioritize my physical and mental health. I worried that the delay would mean missed opportunities, but I now have more time to participate in scientific events, develop friendships, and stand out in classes. When I found out that I was accepted to an exciting writing internship, I realized that saying no to certain options is saying yes to others. I may not graduate in the expected time for most people, but I’m graduating in the right time for me, while doing something I love: communicating science in an accessible, entertaining, and useful way.

Camila Fonseca Amorim da Silva Olá, Ciência!, University of S?o Paulo, S?o Paulo 03828-000, Brazil. Email: camilafonsecaamorim@usp.br

I signed up for a course at a local museum, hoping for a research experience. On my first day, however, I realized that I had accidentally signed up for an intensive writing seminar. Little did I know that the course would expose me to an area of science that would prove invaluable in my career. The seminar taught me how storytelling is central to sharing scientific discoveries. Were it not for that seminar, I would never have undertaken journalism internships, developed a passion for science writing, or become as thoughtful a scientist.

Divyansh Agarwal Massachusetts General Hospital, Harvard Medical School, Boston, MA 02108, USA. Twitter: @divyansh_aga

Reaffirmed values

Several years after publishing our research findings, we realized that we had made some errors. We promptly contacted the journal, which decided to retract the manuscript. Because we had been transparent, we were allowed to submit a corrected version, which was later accepted. Although retractions are often seen as academic failures, going through the process reminded me that integrity and honesty are the cornerstones of our research and made me feel more committed to our values as scientists.

With only a bachelor’s degree in physics and chemistry and a sense of purpose, I tried to create a hydroponic system that would lower the price margins in my country and provide fresh, organic, and affordable vegetables. The journey was rough, and the start-up suffered heavy financial losses. However, my efforts led to more fresh organic produce in Trinidad’s supermarkets, an award for ingenuity, and two publications. Those successes inspired me to venture into medical research, where I found opportunities that brought me closer to my ultimate goal of contributing meaningfully to humanity.

Stephanie Mohammed Department of Physics, Faculty of Science and Technology, The University of the West Indies, St. Augustine Campus, Trinidad, St. Augustine, Trinidad and Tobago. Email: stephanie.mohammed@sta.uwi.edu

Passion for teaching

As a first-generation undergraduate, I was excited to be accepted by a PhD program in zoology immediately after I graduated. However, I didn’t take the time to consider my career goals, and after a year of frustration, I began to doubt whether I was cut out for grad school. Because my solace from research struggles was instructing undergraduate biology, a mentor recommended looking into discipline-based education research programs. Only after I was accepted into a doctoral program in biological education did I realize how wonderful research could be.

I planned to major in chemistry and then work in the lab of some industry or research facility. However, after failing to receive a scholarship I applied for, I had to find another source of income. I had never thought of myself as a teacher before, but I took a job preparing students for their final exams. Suddenly, I realized that teaching was my vocation and quickly updated my academic plan. Now an assistant professor at the university level, I aim to help students follow this path, one I may never have found if I had secured that scholarship.

Improved procedures

After my manuscript was published, I realized, to my horror, that we had used identical reference protein images in two separate results. I checked my original data archives and discovered how difficult it was to find the raw images. After providing the right pictures to the journal, I immediately asked a computer expert to help me develop a better data storage system. Now I upload my raw data daily, all processed data is organized and saved, and all files are backed up weekly. Publishing a mistake taught me the importance of proper data management.

Yongsheng Ji Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230026, China. Email: jiys2020@ustc.edu.cn

Once, after a chemistry experiment, I poured liquid waste containing ammonia directly into the toilet. The strong odor it produced did not go unnoticed by my supervisor. Remembering the smell and the subsequent criticism I received has motivated me to take extreme care when conducting and cleaning up experiments ever since, possibly saving me from accidents and injuries.

Yuan Zhi School of Economics, Guizhou University, Guiyang, Guizhou 550025, China. Email: yzhi@gzu.edu.cn

New research avenues

One night during medical school, my last task was to take out two western blots for two different experiments and place them in antibodies specific against different proteins. The next day, I realized that in my exhaustion I had swapped the blots. Because of this silly mistake, I stumbled upon a novel modification of my protein of interest! The solution to a 2-year mystery came into focus. This serendipitous finding led me to pursue a full-time PhD course to explore a new avenue of research.

Bryce W. Q. Tan Department of Medicine, National University Hospital, Singapore 119228, Singapore. Email: bryce_tan@nuhs.edu.sg

After a tough semester in my undergraduate physics education, I had not completed enough courses to be eligible to continue with the mandatory undergraduate thesis project the same year. I was devastated. Soon afterward, I discovered a new field of research that sparked my interest. The field—biophysics—was outside the traditional topics offered at my institution, but I found a research group and convinced the institution to let me do a biophysics project. Had I not failed and postponed my thesis, I would probably not be working in biophysics today.

Cathrine Bergh KTH Royal Institute of Technology, 11423 Stockholm, Sweden. Email: cabergh@kth.se

Supportive relationships

Because I initially overlooked the acceptance email for a summer program, I missed the window to submit my preferences. I was auto-matched to a venom lab, where I learned to my consternation that I would be hand collecting spiders at midnight from a forest. However, this unexpected topic came with enthusiastic mentors. No snake, turtle, or scorpion went without a photo, and the group took lengthy detours just to appreciate the scenery. I was new to research, and good mentorship and memorable experiences outweighed all else. The experience fueled my interest in pursuing science as a career.

Jackson Ross Powell Vagelos Molecular Life Sciences Program, University of Pennsylvania, Philadelphia, PA 19104, USA. Email: jrp24@sas.upenn.edu

In high school, I found a welcoming mentor who catalyzed my love for research. I asked him if I could work in his lab during the summer, and he jumped through hoops to include me. When I told him later that I had applied to other programs as well and had accepted another offer, he was understandably livid. By taking him for granted and failing to understand the logistics of lab staffing, I ruined my relationship with him.?Today, remembering my mistake constantly reminds me to appreciate and communicate with my mentors.

參考信息：

https://www.science.org/doi/10.1126/science.adg1443

https://xcb.ahmu.edu.cn/2023/0110/c4510a131961/page.htm

原創(chuàng)文章，作者：菜菜歐尼醬，如若轉載，請注明來源華算科技，注明出處：http://www.xiubac.cn/index.php/2024/02/19/5f80de358f/

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厲害了！“雙非”本科生短評登上Science！

The fruits of failure

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厲害了！“雙非”本科生短評登上Science！

The fruits of failure

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